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USA Wager NFL Predictions | Week 1 | September 9, 2021

USA Wager NFL Predictions | Week 1 | September 9, 2021

by Erik NeffSeptember 9, 2021

Welcome to USA Wager’s Weekly NFL Predictions. Let us do the hard work before you head to the sportsbook. Keep up with our Weekly Predictions and our daily NFL Game Predictions all season long.

That time of the year is upon us folks, the first week of the 2021 NFL season. We have a full slate of games in Week 1, kicking off Thursday night with the Bucs and Cowboys. Thursday’s game won’t be in our NFL predictions this week, but we won’t be mad if you want to bet on the Bucs ML.

Let’s take a look at USA Wager’s NFL predictions, betting odds and lines, and sum it all up for Week 1 of the 2021 NFL Season. We have 8 bets for you this week and they are all on Sunday, September 12th.

(USA Wager’s NFL Predictions (picks) are highlighted in Green)


Sun, Sept 12 PIT Steelers+6.5 (-115)+240O 48.5 (-110)
1:00 EST @ BUF Bills-6.5 (-105)-305U 48.5 (-110)
Sun, Sept 12 SF 49ers-8 (-110)-365O 44.5 (-110)
1:00 EST @ DET Lions+8 (-110)+280U 44.5 (-110)
Sun, Sept 12 GB Packers-3.5 (-105)-195O 49.5 (-110)
4:25 EST @ NO Saints+3.5 (-115)+165U 49.5 (-110)
Sun, Sept 12AZ Cardinals+3 (-120)+140O 52.5 (-110)
1:00 EST @ TEN Titans-3 (+100)-160U 52.5 (-110)
Sun, Sept 12CHI Bears+7.5 (-110)+320O 46.5 (-110)
8:20 EST@ LA Rams-7.5 (-110)-425U 46.5 (-110)

(All lines provided by DraftKings)


Breaking Down the Matchups | NFL Predictions

Steelers vs Bills

Game summaries coming soon…

USA Wager Prediction: Bills -6.5 (-105) | U 48.5 (-110)

49ers vs Lions


USA Wager Prediction: 49ers -8 (-110) | U 44.5 (-110)

Packers vs Saints


USA Wager Prediction: Packers -3.5 (-105) | O 49.5 (-110)

Cardinals vs Titans


USA Wager Prediction: Titans -3 (+100)

Bears vs Rams


USA Wager Prediction: Rams -7.5 (-110)


Return to USA Wager every day for our Daily MLB Predictions and Picks, Daily NFL Game Predictions, and Weekly NFL Predictions. This is one ride that you won’t want to get off of!

If you enjoyed our Weekly NFL Predictions – our Daily NBA Predictions are coming soon!


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About The Author
Erik Neff
Erik has played many roles for Knup Solutions over the years including Sports 2.0 admin, site mgmt, content creation, and writing. An avid card collector, sports fan, musician, and family man, Erik continues his journey trying to grow the Sports 2.0 Network to a household name. You can find his work across the Sports 2.0 Network and up and down his Twitter feed. He is also the biggest St. Louis Cardinals fan in the world.