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Cardinals vs 49ers Prediction & NFL Odds for Week 9
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Cardinals vs 49ers Prediction & NFL Odds for Week 9

by Tom ZwillerNovember 3, 2021
  • Kyler Murray will play this week despite being day-to-day.
  • The 49ers will use Trey Lance in the run game, and he will score a rushing touchdown.
  • The 49ers will be able to rush for 120+ yards.

The Arizona Cardinals were one of the hottest teams in the NFL, starting undefeated through their first seven games. That streak ended when the short-staffed Green Bay Packers came to Pheonix and won 24-21.

The Cardinals are looking to get a rebound against the 49ers, who they defeated earlier in the season 17-10. It will be a crucial divisional win if the Cardinals want to remain ahead of the LA Rams (they currently have the head-to-head tiebreaker).

The 49ers, on the other hand, are 3-4 and went on a four-game losing streak before beating the Chicago Bears 33-22 on the road. The 49ers are not looking to stay ahead of the NFC West, but rather to get back into it as they are three games behind the Rams and 49ers.

Betting Odds & Lines for This Game

Cardinals vs 49ers Prediction: Spread

It is never a guarantee, but I always love starting with the record ATS for each team.
The Arizona Cardinals are 6-2 against the spread, while the 49ers are 2-5.
Of course, it is much easier to get more specific: the Cardinals are 4-0 ATS when on the road, whereas the 49ers are 0-3 when home.

However, a prior record is not everything. This spread is incredibly close; practically a pick them, which of course, indicates that Vegas does not know how to call this one.
I feel that the 49ers played the full-strength Cardinals so well, and now that Arizona has an injured (or at best) a limited Kyler Murray.

Because of the 49ers’ matchup ability against the Cardinals and the fact that the 49ers have home-field advantage, I am inclined to have the 49ers beat the spread (and get the win, but that is in the money line).

  • Free Prediction: The 49ers will beat the +1 spread.

Cardinals vs 49ers Prediction: MoneyLine

I think that the 49ers are a team that is much better than its record. The 49ers lost a close one to the Packers, a close one against Seattle (where Jimmy G was injured), a close game against the Cardinals, and an incredibly oddball loss to the Colts in a downpour.

I also think that the Cardinals are slightly better than their record would indicate. The Cardinals could have relatively easily lost to the Vikings, so in my eyes, they are a little closer to 6-2 as opposed to 7-1.

I also think that the loss of JJ Watt is going to make a lousy rushing defense worse than it already was.

Looking back at the first Cardinals loss, they only possessed the ball for 22.5 minutes, primarily due to the Packers’ rushing attack racking up 151 yards. This is not the only time the Cardinals have been out-possessed.

The first team to do it? The 49ers. It was a slight TOP advantage, just 32 minutes to 28, but that still matters.

In games where the Cardinals have been out-possessed, they are 1-1 and have a +4 PD.

In their prior matchup, the 49ers also held Kyler Murray to his third-worst Passer Rating of the season, and that was when he was full strength.

I believe that the 49ers’ ability to run the ball and the injury to Murray will allow the 49ers to get the upset win.

  • Free Prediction: The 49ers will upset the Arizona Cardinals.

Cardinals vs 49ers Prediction: Total

Much like I did with the spread, I like looking at the team’s record against the total. The Cardinals have underperformed against the total this season; they are currently 3-5 on their games hitting the over. They are better against the total on the road, where they are 2-2.

The 49ers, surprisingly, are 4-3 against the total and are 2-1 on their games, hitting the over at home.

Of course, hidden within those data points is the two teams’ prior matchup, in which the total was 49, but the two teams only combined for 27.
A large part of that was (as I discussed above) the fact that the Cardinals rank 24th in rushing yards against, allowing 120 yards per game. In their last game, the 49ers were able to rush for 150 yards and averaged 5.4 per carry.

After the Packers were able to exploit the Cardinals similarly (151 rushing yards and a TOP of 37:35), I anticipate the 49ers to rush the ball, possess it for as long as possible, and chew the clock.

  • Free Prediction: Cardinals @ 49ers will hit the under.

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About The Author
Tom Zwiller
Tom Zwiller is currently attending Holy Cross College where he is majoring in business analytics and minoring in Computer Science, Mathematics, and Theology. During high school, Tom played as a DT on his varsity football team and as a forward for his varsity high school hockey team. Tom loves all things sports, specifically the NFL, the NBA, and the NHL, as well as a good game of table tennis. Go Panthers!