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Cardinals vs 49ers Prediction & NFL Odds for Week 18
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Cardinals vs 49ers Prediction & NFL Odds for Week 18

by USA WagerJanuary 3, 2023

Check out our free Cardinals vs 49ers prediction for the NFL week 18 game in Santa Clara. See who USA Wager likes to win and cover the spread in this football game. And, get our insight into the best over-under point total bet.

Cardinals vs 49ers Prediction & NFL Odds for Week 18

On Sunday, January 8th, the Arizona Cardinals travel to take on the San Francisco 49ers at Levi’s Stadium. This NFC West showdown has a kickoff time set for 4:25 PM ET, and will be televised on FOX.

Heading into Sunday’s game, San Francisco is the odds on favorite to come away with the win. Will they be able to take care of business at home? Or, does Arizona have what it takes to make things interesting? Keep reading to USA Wager’s Cardinals vs 49ers prediction.

  • Spread: ARI +14.0 | SF -14.0
  • MoneyLine: ARI +603 | SF -954
  • Total: 40.0

Cardinals vs 49ers Prediction: Spread

Going into week 18, Arizona has a record of 1-4 in the NFC West. Overall, the Cardinals head into action with a record of 4-12. With this record, the team is in the bottom half of the league in point differential. For the season, they have an average scoring margin of -5.25 points per game. So far, the Cardinals have been favored in 13 of their 16 games. The average point spread in these matchups is 5.

Through their last 5 road games, Arizona has an ATS record of just 2-3. However, their overall record was 1-4-0 while averaging 19.2 points per game. The Cardinals have a straight up record of 0-5 in their previous 5 games as the underdog. Against the spread, they had a mark of 3-2.

Going into week 18, San Francisco has a record of 5-0 in the NFC West. Overall, the 49ers head into action with a record of 12-4. On the season, San Francisco has one of the better scoring margins in the NFL, ranking 2nd with an average differential of 9.25 points. So far, the 49ers have been favored in 14 of their 16 games. The average point spread in these matchups is -6.

Across their last 5 home contests, San Francisco has been good against the spread posting a mark of 4-1. Their overall mark in these games was 5-0, while averaging 28.0 points per game. In their last 5 games as the betting favorite, the 49ers have a strong straight up record of 5-0. In addition, their ATS record was 4-1 in these scenarios.

This week, our projections point to the Cardinals covering the spread in their matchup vs San Francisco. Although the team is far from a prolific passing offense, we see them performing well in week 18.

Free Spread Prediction: Arizona Cardinals 14.0

Cardinals vs 49ers Prediction: Total

Heading into this week’s matchup, the Cardinals have an over-under record of 8-7-1. For the season, the Cardinals offense has been struggling, averaging just 20.44 points per game. Things haven’t gone any better on defense, where they are the 29th ranked scoring defense in the NFL. On the other side, heading into this week’s matchup, the 49ers have an over-under record of 8-8. For the season, San Francisco has been one of the top performing offenses averaging 25.75 points per contest. In addition, the team has been tough on the other side of the ball, ranking 1st in points allowed.

If looking to place a wager on the over-under, our projections see this game finishing with a total of 46 points, making the over the best bet.

Free Total Prediction: Over 40.0

Check out this post for a full list of our weekly NFL predictions‘>weekly NFL predictions


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