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49ers vs Lions Prediction & NFL Odds for Week 1

49ers vs Lions Prediction & NFL Odds for Week 1

by Jacob DeanSeptember 7, 2021
  • Trey Lance will sit and learn
  • Jared Goff under center
  • 49ers will cover the spread

After months of waiting and the three weeks of preseason, the NFL regular season is finally back. On Sunday, the San Francisco 49er’s are on the road to face the Detroit Lions. Kick off is set for 1 P.M. ET at Ford Field.

San Francisco won two of their three games during the preseason and will probably end up starting veteran quarterback Jimmy Garoppolo in the opener. Trey Lance will have to wait a few weeks before he is calling the plays but the noise has been loud surrounding the No. 3 pick in this year’s draft.

The Lions are in a full rebuild but are looking to start off strong under new first year head coach Dan Campbell. Jared Goff is now under center for the Lions as he was involved in an offseason trade that sent Matt Stafford back to LA. In his career Goff has a 3-5 record against the 49ers.

Betting Odds & Lines for This Game

  • Spread: SF -7.5, Detroit + 7.5
  • Moneyline: SF -330, Detroit +270
  • Total: 51.5

All odds listed are courtesy of PointsBet.

49ers vs Lions Prediction: Spread

The San Francisco 49ers are currently 7.5 point favorites to defeat the Detroit Lions. These two teams are in different phases of their plans for the 2021 season. The 49er’s had a disappointing 2020 campaign thanks to injuries but with an up and coming roster and the new addition of Trey Lance this team is looking at a bounce back.

The Lions under new head coach are strong contenders for a top pick in the upcoming 2022 draft. This team is in a rebuild but has some nice pieces to make this contest competitive but this game is still in the Niners favor despite being on the road.

  • Free Prediction: 49ers -7.5

49ers vs Lions Prediction: Moneyline

The 49ers have a superbowl caliber roster and despite the injury riddled season from a season ago, this team is healthy and is looking to put together a run to get back into playoff contention. Jimmy G will be on a short leash heading into the season and given Lance’s performance in the preseason Kyle Shanahan will not hesitate to pull the plug and replace his veteran play caller.

The Detroit defense gave up 32 points per game a season ago and overall the team has not improved much. Offensively the team has some nice weapons and could quietly keep this game close for some time.

San Francisco is 10-1 in it’s last 11 games against Detroit while Detroit is 1-11 in it’s last 12 home games.

  • Free Prediction: 49ers

49ers vs Lions Prediction: Total

The total for this game suggests a high scoring affair at 51.5 points. The 49ers’ offense and defense should be able to put up some points against a Lions defense that is young and growing but the 49er’s rely on their running game and defense. The Lions should keep this game within reason but come up short.

The total has hit the under in six of the Niners last nine home games against Detroit and the total has hit the under in four of Detroit’s last five contests against the NFC West.

  • Free Prediction: Under 51.5 Points

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About The Author
Jacob Dean