49ers vs Cardinals Prediction & NFL Odds for Week 11

Check out our free 49ers vs Cardinals prediction for the NFL week 11 game in Mexico City. See who USA Wager likes to win and cover the spread in this football game. And, get our insight into the best over-under point total bet.

49ers vs Cardinals Prediction & NFL Odds for Week 11

On Monday, November 21st, the San Francisco 49ers travel to take on the Arizona Cardinals at Estadio Azteca. This NFC West showdown has a kickoff time set for 8:15 PM ET, and will be televised on ESPN.

Heading into Monday’s game, San Francisco is a strong favorite to come away with the win. But, can Arizona take advantage of playing at home and pull off the upset? Keep reading to USA Wager’s 49ers vs Cardinals prediction.

• Spread: SF -8.0 | ARI +8.0
• MoneyLine: SF +-350 | ARI 276
• Total: 43.5

49ers vs Cardinals Prediction: Spread

Going into week 11, San Francisco has a record of 3-0 in the NFC West. Overall, the 49ers head into action with a record of 5-4. On the season, San Francisco has one of the better scoring margins in the NFL, ranking 9th with an average differential of 3.89 points. So far, the 49ers have been favored in 7 of their 9 games. The average point spread in these matchups is -5.

Across their 5 previous road games, San Francisco has an ATS mark of 2-3. Their straight up record in these matchups was 2-3-0 while averaging 20.4 points per game. Going back to their previous 5 games as the favorite, San Francisco has an ATS mark of 2-3 while going 3-2 straight up.

Going into week 11, Arizona has a record of 1-3 in the NFC West. Overall, the Cardinals head into action with a record of 4-6. With this record, the team is in the bottom half of the league in point differential. For the season, they have an average scoring margin of -2.8 points per game. So far, the Cardinals have been favored in 7 of their 10 games. The average point spread in these matchups is 4.

Although Arizona has a straight up record of 1-4 in their last 5 home games, they have not held up as well vs the spread going 2-3. The team averaged 22.6 points per game in these games. In their last 5 games as the underdog, Arizona has gone 3-2 vs the spread. Straight up, the team went 2-3 in these matchups.

Going into this week’s matchup, we see the best bet being to take the Cardinals to come away with a win and cover. Although the team has yet to find their groove on offense ranking just 18th and 19th in passing and rush yards, we see them generating enough production to get the job done.

Free Spread Prediction: Arizona Cardinals 8.0

49ers vs Cardinals Prediction: Total

Heading into this week’s matchup, the 49ers have an over-under record of 3-6. So far, the 49ers have found the most success on defense, ranking 4th in points allowed. On offense, they are closer to the NFL average at 22.0 points per game. On the other side, heading into this week’s matchup, the Cardinals have an over-under record of 5-4-1. This season, the Cardinals are averaging 23.0 points per contest, placing them 13th in the league. Defensively, the team is ranked just 30th in points allowed per game.

In this week’s matchup, we see the 49ers and Cardinals combining for 41 points, leading us to recommend taking the under.

Free Total Prediction: Under 43.5

Check out this post for a full list of our weekly NFL predictions‘>weekly NFL predictions