Penn State vs Indiana Prediction & College Football Odds for Week 6

• Indiana’s third game against a team currently ranked in the top 10.
• Penn State leads the all-time series 22-2.
• Indiana beat Penn State 36-35 in OT last season.

Indiana and Penn State meet for the first time since last year’s classic in Bloomington. A controversial finish gave Indiana their second win against Penn State in program history.

• Check out our Cowboys vs Panthers prediction

Penn State enters the game 3-1 against the spread, with three of their four games hitting the under. Penn State failed to cover last week at home against Villanova, a game they controlled from start to finish.

Indiana is currently 0-3 against the spread with two of their contests going over the total. Indiana’s ATS record includes two losses to ranked opponents.

Betting Odds & Lines for This Game

• Spread: Penn State -12.5
• MoneyLine: PSU (-510) Indiana (+375)
• Total: 53.5

All odds listed are courtesy of (DraftKings)

Penn State vs Indiana Prediction: Spread

• Free Prediction: Penn State -12.5

Indiana’s struggles offensively will be highlighted against the stout Penn State defense. With a key injury to receiver DJ Matthews not making anything easier for the Hoosiers.

Saturday Night. Stripe Out.#WeAre | @Highmark pic.twitter.com/2rNyfZn5Nk

— Penn State Football (@PennStateFball) September 28, 2021

Penn State feels as if they were screwed out of a win last year in Bloomington, and has been waiting to take it to Indiana. An electric atmosphere, in prime time, in Happy Valley, it’s hard to picture anything other than Penn State rolling on Saturday.

There might be some value on the Hoosiers if this line climbs to 14. The line opened at 10.5 and has been slowly climbing.

Penn State vs Indiana Prediction: Total

• Free Prediction: Over 53.5

Despite the strength of the two defenses and an anemic Indiana offense, this game has been highlighted as a clear reverse-line movement.

With 54% of the tickets, and 78% percent of the money on the under, the total has climbed from 52 to 53.5.

Despite all of the football reasons to take the under, the line movement screams this game going over the total.

Indiana’s last two contests have gone over the total, suggesting that they may have found some offensive rhythm. Penn State went over for the first time all year against Villanova.

Bet on This College Football Game

Check out this post for a full list of our weekly college football predictions.

Bet the Props

Enter the team or player you’d like to find prop bets for and search below.