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Florida State vs Louisville Prediction & College Football Odds for Week 4
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Florida State vs Louisville Prediction & College Football Odds for Week 4

by Tanner KernSeptember 23, 2021
  • Louisville dominates Florida State
  • The Cardinals cover the spread
  • Both teams combine to exceed the game total

The Louisville Cardinals head down to Tallahassee, Florida to face the struggling Florida State Seminoles in a Saturday early evening matchup.

The Cardinals bring a well-balanced offense to this game that is led by their Junior Quarterback, Malik Cunningham. They currently hold a 2-1 record in which they have won their past two games over Eastern Kentucky and UCF.

Florida State, on the other hand, comes into this one with a very disappointing 0-3 record with losses to Notre Dame, Jacksonville State, and Wake Forest. Since their Week 1 loss, the Seminoles have been unable to produce over 20 points on offense.

Betting Odds & Lines for This Game

  • Spread: Louisville -2
  • Moneyline: Louisville -120, Florida State +100
  • Total: 62.5 points

All odds listed are courtesy of (PointsBet | Caesars | DraftKings | Fanduel | BetRivers)

Florida State vs Louisville Prediction: Spread

This game features two teams trending in two different directions. Florida State had high expectations coming into the 2021 season but hopes quickly have faded after three devastating losses. It seems that constant turnovers force the Seminoles to play from behind in games and therefore ultimately lead to defeats. Things look bleak at FSU and they aren’t showing any signs of improving.

Louisville’s offense is red hot right now and is coming off of a close victory over UCF. The Cardinals can become a major player down the stretch in the ACC title race with a victory against the Seminoles. If they can maintain possession and put up an early lead this can swing in the Cardinals favor quickly.

  • Free Prediction: Louisville 35 Florida State 28

Florida State vs Louisville Prediction: Moneyline

Florida State has underperformed each Week so far this season. With Louisville coming into town with their offense clicking on all cylinders, all signs point to FSU underperforming this week as well.

This is the Louisville Cardinals game to lose. They come in with higher expectations, better recent performance, and overall better quarterback play.

If Louisville can win the turnover battle, the Cardinals should control this one whistle to whistle.

  • Free Prediction: Louisville Wins, Moneyline -120

Florida State vs Louisville Prediction: Total

Both of these offenses have the potential and ability to explode for points in any contest. Florida State is averaging 23 points per game coming into this contest while Louisville has a point per game average of 32.

The biggest game-changing play in this Week’s matchup will be the ball security from the quarterbacks. Through three games, FSU has thrown 7 interceptions while the Cardinals have thrown only 2. If the Seminoles cant secure the ball, expect Louisville to capitalize on the turnovers and explode offensively.

It will be close, but these two offenses will hit their point expectation in this matchup.

  • Free Prediction: Both teams will combine for OVER 62.5 points

Bet on This College Football Game


Check out this post for a full list of our weekly college football predictions.

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About The Author
Tanner Kern
Tanner Kern is a former Division I football player at Lafayette College and a graduate of the University of Connecticut. He is currently a writer for Knup Sports and the Sports 2.0 Network. He is the host of Between the Lines, the official show of Baseball Spotlight, and the main contributor for the website. Sports Network: sports20.com, usawager.com, knupsports.com, baseballspotlight.com, basketballarticles.com, betdecider.com, njsportsbookreview.com, dunkelindex.com, sportspub.com & oddschoice.com