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49ers vs Rams Prediction & NFL Odds for Week 2
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49ers vs Rams Prediction & NFL Odds for Week 2

by USA WagerSeptember 13, 2023

On Sunday, September 17th at 4:05 PM ET, the Los Angeles Rams and San Francisco 49ers face off at SoFi Stadium in Inglewood, CA. FOX will carry the TV coverage for the game.

In a matchup between two NFC West teams, the 49ers are 8 point favorites on the road. Find out my best bets on the spread, total and moneyline.

Prediction at a Glance for Rams vs 49ers

  • Lock in the Rams at +8 while you can.
  • Best moneyline bet goes in favor of the Rams.
  • Strong lean on the under at 44.5.

Betting Odds & Lines for this Game

  • Spread: 49ers -8 | Rams +8
  • Total: 44.5
  • MoneyLine: 49ers -349 | Rams +277

All Odds are courtesy of (BetMGM | DraftKings | Fanduel | BetRivers)

49ers vs. Rams Prediction: Spread

San Francisco has put together a record of 2-1 over their past three games. Against the spread, the team is 2-1 in these same games while going 0-3 on the over/under. Across their last five road contests, San Francisco has been good against the spread posting a mark of 3-2. Their overall mark in these games was 4-1, while averaging 26 points per game.

Over their last three games, the Rams have gone 2-1 straight up. Against the spread, the team is 3-0 in these same games while going 2-1 on the over/under. Across their last five home contests, Los Angeles has a 3-2 record vs the spread. Their overall mark in these games was 1-4, while averaging 15 points per game.

Los Angeles displayed a strong defensive performance in their recent game against Seattle. I’m placing my bet on them to cover the spread, with the current line at +8.

  • Free Spread Prediction Rams +8 (Bet Now)

49ers vs. Rams Prediction: MoneyLine

The 49ers opened the season by facing the Cardinals at home, resulting in a 38-13 win. Against Arizona, quarterback Brock Purdy had a passer rating of 141 while completing 75% of his passess. Overall, he ended the game with 178 yards through the air.

To kick off their season, the Rams hit the road to face the Seahawks, but they suffered a 19-16 loss. Now, they stand at 0-1 going into week two. Baker Mayfield finished the game with 147 passing yards on a completion percentage of 50%. Throughout the game, Mayfield was under pressure, getting sacked five times and throwing one interception.

Los Angeles displayed a strong defensive performance in their recent game against Seattle. I’m placing my bet on them to cover the spread, with the current line at +8.

  • Free MoneyLine Prediction Rams +277 (Bet Now)

49ers vs. Rams Prediction: Total

After combining with the Cardinals for 51 points, the 49ers have started of their season with an over/under record of 0-1. The over/under line going into the game was 40.

Their first game of the season finished with 35 points, which was 5th in the league for the opening week. Their over/under record to start the season is 0-1.

With the over/under line sitting at 44.5, my pick is to take the under. So far, San Francisco has an average margin vs. the over/under of -4.5 points per game.

  • Free MoneyLine Prediction UNDER 44.5 (Bet Now)

Bet on This NFL Game

Check out this post for a full list of our weekly NFL predictions

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